Ipamorelin
Ipamorelin
Clean GH pulse without cortisol elevation
About
A selective ghrelin receptor agonist that stimulates growth hormone release without raising cortisol or prolactin.
Mechanism
Binds GHS-R1a receptors in the pituitary and triggers a clean GH pulse.
Dosage
Draw to 2 units on a U-100 insulin syringe
10 mg · 2 mL BAC
When to take: On an empty stomach, 30-60 min before food or sleep. Important: no food for 30-60 min after.
Reconstitution
Vial size (mg): 10 mg · BAC water (mL): 2 mL · Concentration: 5000 mcg/mL
Often blended with CJC-1295 in the same syringe.
Dosing reference
Units to draw at the typical dose range, per vial size.
| Vial | Water | Typical draw |
|---|---|---|
| 10 mg | 2 mL | 4–6 units |
Benefits
- Natural GH elevation
- Improved sleep
- Muscle building
- Fat loss
- Improved skin and hair quality
- No cortisol elevation
Side effects
- Tingling in hands (transient)
- Vivid dreams
- Transient headache
- Mild hunger
Gender notes
Cautions
- Active cancer (hard contraindication)
- Pregnancy and breastfeeding
- Diabetes (monitor blood glucose)
- Pituitary tumors
Research
- Raun H et al: Ipamorelin selective GH release without ACTH/cortisol
European Journal of Endocrinology · 1998
Key study showing ipamorelin stimulates GH without elevating cortisol or ACTH.
- Sinha DK et al: Clinical applications of GH secretagogues
Translational Andrology and Urology · 2020
Review of GH secretagogues in clinical use.